FAQ's About Nanotechnology

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What benefits do nanotube surfaces have compared to other implant surfaces?
Increased Hydrophilicity:  Many studies have shown that hydrophilic surfaces enhance the way bone cells attach to implants.  The Nanovation nanotube surface treatment converts the slightly hydrophilic titanium implant surface to a super-hydrophilic surface which measurably accelerates the bone cell attachment activities.  
This increase in the hydrophilic properties of the surface is measured by the reduction of the water droplet contact angle from 54° for untreated titanium to less than 4° for the Nanovation nanotube surface.  This allows cell drawn to the nanotube array surface to flatten and spread out on the surface.
Improved Surface Morphology:  Adding billions of nanotubes per square centimeter of implant surface substantially increases the surface area of the implant interacting with the surrounding bone cells.  This is significantly more surface area as compared to other processes that form structures that modify the implant surface only on the macro and micro level.  The unique geometry of the nanotubular arrays presents billions of nanotube edges on a typical implant that results in a charge distribution that has been shown to be beneficial to cell adhesion in vitro.  Additionally, the UCSD research has shown that the diameter of the nanotubes can be tuned to enhance the proliferation of different cell types.

Increased Osseointegration: Nanotube array surfaces enhance osseointegration, signal the local stem cells to adhere, increase cell differentiation to osteoblast cells, and induce these osteoblast cells to incorporate to the implant surface. These properties have all been well documented by thirty-two journal papers published in international journals from Professor Sungho Jin's group at UC San Diego (the inventors for the TiO2 nanotube biomaterials) over the past decade (during which five PhD students successfully completed their thesis work on TiO2 nanotube biomaterials and two post-doctorates also conducted active research on the subject).  

Nanotubes encourage early cell attachment.  Bone formation is shown by assays for calcium and phosphorous deposition.  Genetic up-regulation for osteoblast cells occurs.  The end result is early, comprehensive cell growth and attachment, resulting in substantially better values for in vitro implant adhesion pull out tests, which is an accepted proxy test for osseointegration.  The Nanovation nanotube surface results in a nine (9) times stronger bone adhesion compared to the same roughened titanium surface without nanotubes.

Improved Antimicrobial Properties: Nanotubes and nanotubes enhanced by nano-silver particles have been shown to have improved antimicrobial properties as compared to non-treated surfaces.  These in vitro studies appear in multiple peer reviewed publications authored by researchers world-wide.  These studies, done by researchers not affiliated with Nanovation, have confirmed Professor Sungho Jin’s UCSD Lab’s reports that TiO2 nanotubes enhance antimicrobial properties and Professor Amit Bandyopadhyay’ s Washington State University’s lab that silver nanoparticles on TiO2 nanotubes further enhance antimicrobial properties.  This intellectual property from both Professor Jin’s Lab and Professor Bandyopadhyay’s Lab has been licensed by Nanovation.
Are nanotubes truly an engineered nanotechnology with defined nano features?
What are some of the differences between nanotubes and hydroxyapatite coatings?
Can I follow the nanotube treatment with other manufacturing processes or must the treatment be the last process?
How much will it cost to put nanotubes on our product?
Will the cost change with time?
What kind of marketing support can my company expect to receive from Nanovation?

About Us

Starting in the mid 2000’s, the founders of Nanovation Partners LLC sponsored research at the University of California at San Diego (UCSD) in the lab of Sungho Jin, PhD. This research showed enhanced osseointegration and reduced implant surface infection by forming thousands of rows of tiny metal oxide nanotubes

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